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Pet Medication Dose Calculator

Weight-based OTC medication dosing for dogs and cats — Benadryl, Pepcid, Melatonin and more

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📊 Data: Merck Vet Manual, ASPCA, VCA Hospitals
📅 Updated Mar 2026

💊 Pet Medication Dose Calculator

Weight-based dosing for common OTC medications — dogs and cats

OTC Medications Safe for Dogs and Cats

Several over-the-counter human medications can be used safely in pets at the correct dose. The key word is correct — the wrong dose or the wrong formulation can be dangerous or fatal. This calculator uses weight-based dosing guidelines based on veterinary references.

Most Important Rule: Check Every Ingredient

Many OTC medications come in multiple formulations. “Benadryl-D” contains a decongestant toxic to dogs. Some Pepto-Bismol formulations contain aspirin derivatives. Some peanut butters and melatonin supplements contain xylitol — a sweetener that causes liver failure in dogs. Always read the full ingredient list, not just the product name.

Medications You Should NEVER Give Pets

  • Ibuprofen (Advil, Motrin) — causes kidney failure and stomach ulcers in dogs and cats
  • Acetaminophen (Tylenol) — destroys red blood cells in cats, toxic to dogs in high doses
  • Naproxen (Aleve) — extremely toxic to both dogs and cats
  • Aspirin — toxic to cats, use only under vet guidance for dogs
  • Any decongestant — pseudoephedrine causes seizures and death

When to Call a Vet Instead

OTC medications treat symptoms, not causes. If your pet has been vomiting for more than 24 hours, has blood in stool or urine, is lethargic or in obvious pain, or has potentially ingested a toxin — call your vet or an emergency animal hospital immediately. ASPCA Poison Control: (888) 426-4435.